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Pathol Oncol Res. 2015 Apr;21(2):325-31. doi: 10.1007/s12253-014-9824-4. Epub 2014 Aug 22.

Lantana camara Induces Apoptosis by Bcl-2 Family and Caspases Activation.

Author information

1
Institute of Pharmaceutical Research and Development, College of Pharmacy, Wonkwang University, 460 Ikandae-ro, Iksan, Jeonbuk, 570-749, Republic of Korea.

Abstract

Breast cancer is one of the most common cancers worldwide, and the second most fatal cancer in women after lung cancer. Because there are instances of cancer resistance to existing therapies, studies focused on the identification of novel therapeutic drugs are very important. In this study, we identified a natural anticancer agent from Lantana camara, a flowering plant species of the genus Verbena. The extract obtained from the L. camara exhibited cell death properties in the human breast cancer cell line, MCF-7. We found that the apoptosis induced by treatment with the L. camara extract was regulated by the Bcl-2 family. Bid and Bax was increased and Bcl-2 was decreased by L. camara extract. L. camara extract modulated cleavage of caspase-8, and caspase-9, as well as poly (ADP-ribose) polymerase (PARP). Our results support the potential use of the L. camara extract as an anti-breast cancer drug.

PMID:
25145450
DOI:
10.1007/s12253-014-9824-4
[Indexed for MEDLINE]

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