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J Clin Endocrinol Metab. 2014 Nov;99(11):E2317-24. doi: 10.1210/jc.2014-2143. Epub 2014 Aug 21.

Combination of peptide YY3-36 with GLP-1(7-36) amide causes an increase in first-phase insulin secretion after IV glucose.

Author information

1
Section of Investigative Medicine (T.M.T., V.S., R.C.T., A.A., B.C.T.F., A.D.S., S.M., K.C.R.B., M.D., J.M., M.A.G., S.R.B.), and Department of Endocrinology and Metabolism (I.F.G.), Imperial College London, London W12 0NN, United Kingdom.

Abstract

CONTEXT:

The combination of peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) has been proposed as a potential treatment for diabetes and obesity. However, the combined effects of these hormones, PYY(3-36) and GLP-1(7-36 amide), on glucose homeostasis are unknown.

OBJECTIVE:

This study sought to investigate the acute effects of PYY(3-36) and GLP-1(7-36) amide, individually and in combination, on insulin secretion and sensitivity.

SETTING AND DESIGN:

Using a frequently sampled iv glucose tolerance test (FSIVGTT) and minimal modeling, this study measured the effects of PYY(3-36) alone, GLP-1(7-36) amide alone, and a combination of PYY(3-36) and GLP-1(7-36) amide on acute insulin response to glucose (AIRg) and insulin sensitivity index (SI) in 14 overweight human volunteers, studied in a clinical research facility.

RESULTS:

PYY(3-36) alone caused a small but nonsignificant increase in AIRg. GLP-1(7-36) amide alone and the combination of PYY(3-36) and GLP-1(7-36) amide did increase AIRg significantly. No significant differences in SI were observed with any intervention.

CONCLUSIONS:

PYY(3-36) lacks any significant acute effects on first-phase insulin secretion or SI when tested using an FSIVGTT. Both GLP-1(7-36) amide alone and the combination of PYY3-36 and GLP-1(7-36) amide increase first-phase insulin secretion. There does not seem to be any additive or synergistic effect between PYY(3-36) and GLP-1(7-36) amide on first-phase insulin secretion. Neither hormone alone nor the combination had any significant effects on SI.

PMID:
25144632
PMCID:
PMC4258604
DOI:
10.1210/jc.2014-2143
[Indexed for MEDLINE]
Free PMC Article

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