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Neuron Segmentation in Electron Microscopy Images Using Partial Differential Equations.

Author information

1
Scientific Computing and Imaging Institute, University of Utah.
2
National Center for Microscopy and Imaging Research, Univeristy of California, San Diego.

Abstract

In connectomics, neuroscientists seek to identify the synaptic connections between neurons. Segmentation of cell membranes using supervised learning algorithms on electron microscopy images of brain tissue is often done to assist in this effort. Here we present a partial differential equation with a novel growth term to improve the results of a supervised learning algorithm. We also introduce a new method for representing the resulting image that allows for a more dynamic thresholding to further improve the result. Using these two processes we are able to close small to medium sized gaps in the cell membrane detection and improve the Rand error by as much as 9% over the initial supervised segmentation.

KEYWORDS:

biology; connectomics; electron microscopy; partial differential equation

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