Send to

Choose Destination
Ann Dermatol. 2014 Aug;26(4):447-56. doi: 10.5021/ad.2014.26.4.447. Epub 2014 Jul 31.

The efficacy, longevity, and safety of combined radiofrequency treatment and hyaluronic Acid filler for skin rejuvenation.

Author information

Aesthetic Research Team, Amore Pacific Corporation Research and Development Center, Yongin, Korea.
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.



Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed.


The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections.


A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS).


In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone.


A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation.


Filler; Radiofrequency; Skin rejuvenation

Supplemental Content

Full text links

Icon for Korean Dermatological Association Icon for PubMed Central
Loading ...
Support Center