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J Neurosci. 2014 Aug 20;34(34):11349-54. doi: 10.1523/JNEUROSCI.2558-13.2014.

Spatial irregularities of sensitivity along the organ of Corti of the cochlea.

Author information

1
Knowles Hearing Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208-3550.
2
Knowles Hearing Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208-3550 mruggero@northwestern.edu.

Abstract

Fine structures of spatial profiles were computed from existing records of cat and chinchilla auditory-nerve fibers on the basis of their characteristic frequencies and cochlear maps. The spatial fine structures of characteristic-frequency thresholds and of "spontaneous" and driven firing rates were mutually correlated, implying the presence of sensitivity fluctuations due to spatial irregularities of presynaptic structures or processes of the inner hair cells and their input. These findings suggest that activity that appears spontaneous is not actually spontaneous and may indicate irregularities of tonotopic mapping in cochlear mechanics.

KEYWORDS:

auditory-nerve fibers; cochlea; inner hair cells; organ of Corti; spatial irregularities

PMID:
25143615
PMCID:
PMC4138343
DOI:
10.1523/JNEUROSCI.2558-13.2014
[Indexed for MEDLINE]
Free PMC Article

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