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Am J Physiol Renal Physiol. 2014 Oct 15;307(8):F891-900. doi: 10.1152/ajprenal.00163.2014. Epub 2014 Aug 20.

A current understanding of vascular calcification in CKD.

Author information

1
Division of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; and.
2
Department of Bioengineering, University of Washington, Seattle, Washington ceci@uw.edu.

Abstract

Patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) have significant cardiovascular morbidity and mortality that is in part due to the development of vascular calcification. Vascular calcification is an active, highly regulated process that shares many similarities with normal bone formation. New discoveries related to extracellular vesicles, microRNAs, and calciprotein particles continue to reveal the mechanisms that are involved in the initiation and progression of vascular calcification in CKD. Further innovations in these fields are critical for the development of biomarkers and therapeutic options for patients with CKD and ESRD.

KEYWORDS:

calciprotein particles; chronic kidney disease; microRNA; vascular calcification; vesicles

PMID:
25143458
PMCID:
PMC4200295
DOI:
10.1152/ajprenal.00163.2014
[Indexed for MEDLINE]
Free PMC Article

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