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Pediatr Radiol. 2015 Feb;45(2):203-10. doi: 10.1007/s00247-014-3134-6. Epub 2014 Aug 21.

Diffuse intrinsic pontine glioma: is MRI surveillance improved by region of interest volumetry?

Author information

1
Department of General Radiology, North Tees & Hartlepool NHS Foundation Trust, University Hospital of North Tees, Hardwick Road, Stockton-on-Tees, Cleveland, TS19 8PE, UK, garanriley@hotmail.com.

Abstract

BACKGROUND:

Paediatric diffuse intrinsic pontine glioma (DIPG) is noteworthy for its fibrillary infiltration through neuroparenchyma and its resultant irregular shape. Conventional volumetry methods aim to approximate such irregular tumours to a regular ellipse, which could be less accurate when assessing treatment response on surveillance MRI. Region-of-interest (ROI) volumetry methods, using manually traced tumour profiles on contiguous imaging slices and subsequent computer-aided calculations, may prove more reliable.

OBJECTIVE:

To evaluate whether the reliability of MRI surveillance of DIPGs can be improved by the use of ROI-based volumetry.

MATERIALS AND METHODS:

We investigated the use of ROI- and ellipsoid-based methods of volumetry for paediatric DIPGs in a retrospective review of 22 MRI examinations. We assessed the inter- and intraobserver variability of the two methods when performed by four observers.

RESULTS:

ROI- and ellipsoid-based methods strongly correlated for all four observers. The ROI-based volumes showed slightly better agreement both between and within observers than the ellipsoid-based volumes (inter-[intra-]observer agreement 89.8% [92.3%] and 83.1% [88.2%], respectively). Bland-Altman plots show tighter limits of agreement for the ROI-based method.

CONCLUSION:

Both methods are reproducible and transferrable among observers. ROI-based volumetry appears to perform better with greater intra- and interobserver agreement for complex-shaped DIPG.

PMID:
25142239
DOI:
10.1007/s00247-014-3134-6
[Indexed for MEDLINE]

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