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Biomed Res Int. 2014;2014:874610. doi: 10.1155/2014/874610. Epub 2014 Jul 23.

Alpha-melanocyte stimulating hormone: an emerging anti-inflammatory antimicrobial peptide.

Author information

1
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India ; School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
2
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Abstract

The alpha-melanocyte stimulating hormone (α-MSH) is a neuropeptide belonging to the melanocortin family. It is well known for its anti-inflammatory and antipyretic effects and shares several characteristics with antimicrobial peptides (AMPs). There have been some recent reports about the direct antimicrobial activity of α-MSH against various microbes belonging to both fungal and bacterial pathogens. Similar to α-MSH's anti-inflammatory properties, its C-terminal residues also exhibit antimicrobial activity parallel to that of the entire peptide. This review is focused on the current findings regarding the direct antimicrobial potential and immunomodulatory mechanism of α-MSH and its C-terminal fragments, with particular emphasis on the prospects of α-MSH based peptides as a strong anti-infective agent.

PMID:
25140322
PMCID:
PMC4130143
DOI:
10.1155/2014/874610
[Indexed for MEDLINE]
Free PMC Article

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