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Brain Res. 1989 Dec 4;503(2):334-8.

Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age.

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Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, U.K.


Golgi-impregnated medium-size spiny neurones were studied in the rat neostriatum at various times after a unilateral 6-hydroxydopamine lesion of the medial forebrain bundle. At both short (12-26 days) and long (7-12 months) survival times, the density of spines was significantly lower (13%) on neostriatal neurones ipsilateral to the 6-hydroxydopamine injection. At longer times the density of spines was lower on neurones both ipsilateral and contralateral to the lesion when compared to neurones taken from short-term animals (23%).

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