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J Cell Mol Med. 2014 Sep;18(9):1705-11. doi: 10.1111/jcmm.12349. Epub 2014 Aug 19.

Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases.

Author information

1
Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Ljubljana, Slovenia.

Abstract

Protein misfolding, and subsequent aggregation have been proven as the leading cause of most known dementias. Many of these, in addition to neurodegeneration, show profound changes in behaviour and thinking, thus, psychiatric symptoms. On the basis of the observation that progressive myoclonic epilepsies and neurodegenerative diseases share some common features of neurodegeneration, we proposed autophagy as a possible common impairment in these diseases. Here, we argue along similar lines for some neuropsychiatric conditions, among them depression and schizophrenia. We propose that existing and new therapies for these seemingly different diseases could be augmented with drugs used for neurodegenerative or neuropsychiatric diseases, respectively, among them some which modulate or augment autophagy.

KEYWORDS:

autophagy; neurodegenerative diseases; progressive myoclonus epilepsies; protein aggregation; psychiatric diseases

PMID:
25139375
PMCID:
PMC4196646
DOI:
10.1111/jcmm.12349
[Indexed for MEDLINE]
Free PMC Article

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