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J Neuroimmunol. 2014 Nov 15;276(1-2):224-8. doi: 10.1016/j.jneuroim.2014.08.002. Epub 2014 Aug 8.

Immunosuppressants increase the levels of natural autoantibodies reactive with glycosaminoglycans in myasthenia gravis.

Author information

1
Department of Neurology, Semmelweis University, 1083 Balassa u.6, Budapest, Hungary; Department of Genetics, Cell and Immunobiology, Semmelweis University, 1089 Nagyvárad tér 4., Budapest, Hungary.
2
Department of Pharmacodynamics, Semmelweis University, 1089 Nagyvárad tér 4., Budapest, Hungary.
3
Institute of Enzymology Biological Research Center, Hungarian Academy of Sciences, Karolina u 29, Budapest H-1518, Hungary.
4
Department of Genetics, Cell and Immunobiology, Semmelweis University, 1089 Nagyvárad tér 4., Budapest, Hungary.
5
Institute of Genomic Medicine and Rare Disorders, Semmelweis University, 1083 Tömő u.18, Budapest, Hungary.
6
Department of Genetics, Cell and Immunobiology, Semmelweis University, 1089 Nagyvárad tér 4., Budapest, Hungary. Electronic address: buzas.edit@med.semmelweis-univ.hu.

Abstract

Increasing number of evidences support the role of glycosylation in the evolution of autoimmunity. We examined carbohydrate-reactive natural autoantibodies systematically for the first time in patients with autoimmune myasthenia gravis. Antibodies reactive to glycosaminoglycans were measured with CovaLink ELISA in the sera of 59 myasthenia patients as well as in 54 healthy controls. We used the GlycoChip carbohydrate array to characterize individual carbohydrate recognition patterns. Chondroitin-sulphate C and anti-α-mannose-specific IgG levels were significantly elevated in myasthenia patients. Unexpectedly, we found that immunosuppressants increased the levels of the protective IgM glycosaminoglycan-reactive natural antibodies demonstrating a new role for these agents in immunoregulation.

KEYWORDS:

Autoimmunity; Glycosylation; Muscle

PMID:
25139014
DOI:
10.1016/j.jneuroim.2014.08.002
[Indexed for MEDLINE]

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