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Dement Geriatr Cogn Disord. 2014;38(5-6):321-9. doi: 10.1159/000360606. Epub 2014 Aug 13.

Increased serum levels of interleukin-18, -23 and -17 in Chinese patients with Alzheimer's disease.

Author information

1
Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University,, Shanghai, China.

Abstract

AIMS:

To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), and explore correlations between the three cytokines and relevant parameters.

METHODS:

Serum concentrations of IL-18, IL-23 and IL-17 were measured by ELISA for 53 AD patients and 53 sex- and age-matched healthy controls in a community of elderly individuals in a Shanghai suburb.

RESULTS:

Serum concentrations of IL-18, IL-23 and IL-17 were significantly higher in AD patients than controls. The serum level of IL-23 was observed to be significantly higher (p = 0.049) in female AD patients than male AD patients. In addition, a significantly inverse correlation was found between IL-18 and MMSE score (rs = -0.356, p = 0.011) for all AD patients.

CONCLUSION:

Elevated IL-18, IL-23 and IL-17 levels are observed in AD patients and differences may exist between males and females. Besides, IL-18 may correlate with the severity of AD.

PMID:
25138786
DOI:
10.1159/000360606
[Indexed for MEDLINE]

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