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Planta Med. 2014 Aug;80(13):1113-7. doi: 10.1055/s-0034-1382956. Epub 2014 Aug 19.

Isolation and cytotoxic effect of anthraquinones from Morinda umbellata.

Author information

1
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
2
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan.

Abstract

Four new anthraquinones, 1,6-dihydroxy-2-methoxymethylanthraquinone (1), 6-hydroxy-7-methoxy-2-methoxymethylanthraquinone (3), 3,6-dihydroxy-7-methoxy-2-methylanthraquinone (4), and 6-hydroxy-2-methoxymethylanthraquinone (8), together with 12 known anthraquinones and 6 other known compounds, were isolated from the EtOAc extract of Morinda umbellata. Among the isolated compounds, 1, rubiadin (14), and, 3-hydroxy-2-hydroxymethylanthraquinone (16) exhibited significant cytotoxicities against HepG2 cells, with GI50 values of 4.4, 3.6, and 4.8 ┬ÁM, respectively.

PMID:
25137574
DOI:
10.1055/s-0034-1382956
[Indexed for MEDLINE]
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