Format

Send to

Choose Destination
Nat Immunol. 2014 Sep;15(9):815-23. doi: 10.1038/ni.2938.

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.

Author information

1
Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA.

Abstract

Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. It is now understood that the T cell repertoire is in fact broadly self-reactive, even self-centered. The strength with which a T cell reacts to self ligands and the environmental context in which this reaction occurs influence almost every aspect of T cell biology, from development to differentiation to effector function. Here we highlight recent advances and discoveries that relate to T cell self-reactivity, with a particular emphasis on T cell antigen receptor (TCR) signaling thresholds.

PMID:
25137456
PMCID:
PMC4348363
DOI:
10.1038/ni.2938
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center