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Nat Immunol. 2014 Sep;15(9):808-14. doi: 10.1038/ni.2941.

Serine-threonine kinases in TCR signaling.

Author information

1
Instituto Investigación Sanitaria/Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Madrid, Spain.
2
The College of Life Sciences, Division of Cell Signalling and Immunology, University of Dundee, Dundee, UK.

Abstract

T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Here we explore how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism to meet the metabolic demands of participating in an immune response.

PMID:
25137455
PMCID:
PMC6443032
DOI:
10.1038/ni.2941
[Indexed for MEDLINE]
Free PMC Article

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