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Biomed Opt Express. 2014 Jul 29;5(8):2837-42. doi: 10.1364/BOE.5.002837. eCollection 2014 Aug 1.

Study of freshly excised brain tissues using terahertz imaging.

Author information

1
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea ; issac@yuhs.ac.
2
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
3
Yonsei Institute of Convergence Technology, Yonsei University, Seoul 120-752, South Korea.
4
Nanomedical National Core Research Center, Yonsei University, Seoul 120-749, South Korea.
5
Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
6
Nano Materials Evaluation Center, Korea Research Institute of Standards and Science, Daejeon 305-340, South Korea.
7
Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea.
8
YUMS-KRIBB Medical Convergence Research Institute, College of Medicine, Yonsei University, Seoul 120-752, South Korea ; Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, South Korea.
9
Department of Physics, University of Seoul, Seoul 130-743, South Korea ; joohiuk@uos.ac.kr.

Abstract

We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal brain tissue using a reflection-type terahertz (THz) imaging system. THz binary images of brain tissues with tumors indicated that the tumor boundaries in the THz images corresponded well to those in visible images. Grey and white-matter regions were distinguishable owing to the different distribution of myelin in the brain tissue. THz images corresponded closely with magnetic resonance imaging (MRI) results. The MRI and hematoxylin and eosin-stained microscopic images were investigated to account for the intensity differences in the THz images for fresh and paraffin-embedded brain tissue. Our results indicated that the THz signals corresponded to the cell density when water was removed. Thus, THz imaging could be used as a tool for label-free and real-time imaging of brain tumors, which would be helpful for physicians to determine tumor margins during brain surgery.

KEYWORDS:

(170.3880) Medical and biological imaging; (170.6795) Terahertz imaging

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