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Cancer Res. 2014 Sep 1;74(17):4671-5. doi: 10.1158/0008-5472.CAN-14-1424. Epub 2014 Aug 18.

Mouse models of human cancer.

Author information

1
Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
2
Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany. Experimental and Clinical Research Center, Charité University Medicine, Berlin, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.
3
Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. Molecular Cancer Research Center (MKFZ), Charité University Medical Hospital, Berlin, Germany.
4
Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany. augustin@angiogenese.de.

Abstract

The Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC; www.helmholtz-pccc.de) hosted the "1st International Kloster Seeon Meeting on Mouse Models of Human Cancer" in the Seeon monastery (Germany) from March 8 to 11, 2014. The meeting focused on the development and application of novel mouse models in tumor research and high-throughput technologies to overcome one of the most critical bottlenecks in translational bench-to-bedside tumor biology research. Moreover, the participants discussed basic molecular mechanisms underlying tumor initiation, progression, metastasis, and therapy resistance, which are the prerequisite for the development of novel treatment strategies and clinical applications in cancer therapy.

PMID:
25136075
DOI:
10.1158/0008-5472.CAN-14-1424
[Indexed for MEDLINE]
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