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Antimicrob Agents Chemother. 2014 Nov;58(11):6938-41. doi: 10.1128/AAC.03239-14. Epub 2014 Aug 18.

In vivo efficacy of apramycin in murine infection models.

Author information

1
Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland.
2
Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA.
3
Euprotec Limited, Manchester, United Kingdom.
4
Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland boettger@imm.uzh.ch.

Abstract

Apramycin is a unique aminoglycoside with a dissociation of antibacterial activity and ototoxicity. We assessed the antibacterial efficacy of apramycin in two murine models of infection, Mycobacterium tuberculosis aerosol infection and Staphylococcus aureus septicemia. In both infection models, the efficacy of apramycin was comparable to that of amikacin. These results suggest that apramycin has the potential to become a clinically useful agent against drug-resistant pathogens and support further development of this promising unique aminoglycoside.

PMID:
25136009
PMCID:
PMC4249428
DOI:
10.1128/AAC.03239-14
[Indexed for MEDLINE]
Free PMC Article

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