Send to

Choose Destination
Med Clin North Am. 2014 Sep;98(5):1193-208. doi: 10.1016/j.mcna.2014.06.012. Epub 2014 Jul 12.

Medical conditions with neuropsychiatric manifestations.

Author information

Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 9th Avenue, Box 359892, Seattle, WA 98104, USA. Electronic address:
Medicine, Group Health Research Institute, University of Washington School of Medicine, Seattle, WA, USA.


Medical disease sometimes affects patients through neuropsychiatric manifestations. When neuropsychiatric symptoms are predominant, identifying medical disease early in the illness course is imperative because many of these conditions are reversible with appropriate treatment. A high index of suspicion is required on the part of clinicians, particularly when patients also present with physical signs or unexplained symptoms that might suggest a broader, systemic process. The processes that most commonly cause neuropsychiatric symptoms include infectious, autoimmune, endocrinologic, metabolic, and neoplastic diseases. This article focuses on the most common of these conditions, and conditions for which early diagnosis and treatment are particularly important.


Autoimmune/inflammatory disease; Central nervous system (CNS); Cognitive impairment; Dementia; Mood disorders; Neuropsychiatric symptoms; Peripheral nervous system

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center