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J Am Heart Assoc. 2014 Aug 18;3(4). pii: e001109. doi: 10.1161/JAHA.114.001109.

Red cell distribution width is associated with incident myocardial infarction in a general population: the Tromsø Study.

Author information

1
K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., I.N., E.B.M., S.K.B., J.B.H.) Hematological Research Group (HERG), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., S.K.B., J.B.H.) Division of Internal Medicine, University Hospital of North-Norway, Tromsø, Norway (T.S., S.K.B., J.B.H.).
2
K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., I.N., E.B.M., S.K.B., J.B.H.) Hematological Research Group (HERG), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., S.K.B., J.B.H.).
3
Division of Epidemiology, Department of Family and Preventive Medicine, School of Medicine, University of California San Diego, La Jolla, CA (E.B.C.).
4
K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., I.N., E.B.M., S.K.B., J.B.H.) Hematological Research Group (HERG), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., S.K.B., J.B.H.) Department of Medical Biochemistry, University Hospital of North-Norway, Tromsø, Norway (J.B.).
5
Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (M.L., I.N., T.W.).
6
K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., I.N., E.B.M., S.K.B., J.B.H.) Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway (M.L., I.N., T.W.).
7
K.G. Jebsen Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (T.S., J.L., T.S.E., J.B., I.N., E.B.M., S.K.B., J.B.H.) Brain and Circulation esearch Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway (E.B.M.) Department of Neurology and Neurophysiology, University Hospital of North-Norway, Tromsø, Norway (E.B.M.).

Abstract

BACKGROUND:

Red cell distribution width (RDW), a measure of the variability in size of circulating erythrocytes, is associated with mortality and adverse outcome in selected populations with cardiovascular disease. It is scarcely known whether RDW is associated with incident myocardial infarction (MI). We aimed to investigate whether RDW was associated with risk of first-ever MI in a large cohort study with participants recruited from a general population.

METHODS AND RESULTS:

Baseline characteristics, including RDW, were collected for 25 612 participants in the Tromsø Study in 1994-1995. Incident MI during follow-up was registered from inclusion through December 31, 2010. Cox regression models were used to calculate hazard ratios with 95% confidence intervals for MI, adjusted for age, sex, body mass index, smoking, hemoglobin, white blood cells, platelets, and other traditional cardiovascular risk factors. A total of 1779 participants experienced a first-ever MI during a median follow-up time of 15.8 years. There was a linear association between RDW and risk of MI, for which a 1% increment in RDW was associated with a 13% increased risk (hazard ratio 1.13; 95% CI, 1.07 to 1.19). Participants with RDW above the 95th percentile had 71% higher risk of MI compared with those with RDW in the lowest quintile (hazard ratio 1.71; 95% CI, 1.34 to 2.20). All effect estimates were essentially similar after exclusion of participants with anemia (n=1297) from the analyses.

CONCLUSION:

RDW is associated with incident MI in a general population independent of anemia and cardiovascular risk factors.

KEYWORDS:

blood cells; cardiovascular disease; epidemiology; risk factors

PMID:
25134681
PMCID:
PMC4310408
DOI:
10.1161/JAHA.114.001109
[Indexed for MEDLINE]
Free PMC Article

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