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World J Gastrointest Pathophysiol. 2014 Aug 15;5(3):304-21. doi: 10.4291/wjgp.v5.i3.304.

Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.

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Patricia Sarlos, 1 Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary.


Ulcerative colitis (UC) is one of the main types of inflammatory bowel disease, which is caused by dysregulated immune responses in genetically predisposed individuals. Several genetic factors, including interleukin and interleukin receptor gene polymorphisms and other inflammation-related genes play central role in mediating and modulating the inflammation in the human body, thereby these can be the main cause of development of the disease. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but summarized literature is exiguous for challenge health specialist that can used in the clinical practice nowadays. This review summarizes the current literature on inflammation-related genetic polymorphisms which are associated with UC. We performed an electronic search of Pubmed Database among publications of the last 10 years, using the following medical subject heading terms: UC, ulcerative colitis, inflammation, genes, polymorphisms, and susceptibility.


Genes; Inflammatory factors; Polymorphisms; Susceptibility; Ulcerative colitis

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