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Clin Nutr. 2015 Aug;34(4):694-9. doi: 10.1016/j.clnu.2014.07.015. Epub 2014 Aug 4.

Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population.

Author information

1
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
2
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain.
3
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain.
4
Department of Biochemistry and Genetics, University of Navarra, Pamplona, Spain.
5
Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain. Electronic address: amarti@unav.es.

Abstract

BACKGROUND & AIMS:

Oxidative stress and inflammation seem to be potential underlying mechanisms for telomere attrition. A lack of specific antioxidants is believed to increase free radical damage and a greater risk for telomere shortening. Our aim was to evaluate the relationship between diet and leukocyte telomere length in a cross-sectional study of children and adolescents. We hypothesized that dietary total antioxidant capacity would be positively associated with telomere length.

METHODS:

Telomere length was measured by quantitative real-time polymerase chain reaction in 287 participants (55% males, 6-18 years), who were randomly selected from the GENOI study.

RESULTS:

A positive correlation between dietary total antioxidant capacity and telomere length (r = 0.157, p = 0.007) was found after adjustment for age and energy intake. However, higher white bread consumption was associated with shorter telomeres (β = -0.204, p = 0.002) in fully-adjusted models. Interestingly, those individuals who had simultaneously higher dietary total antioxidant capacity and lower white bread consumption significantly presented the longest telomeres. Moreover, the multivariable-adjusted odds ratio for very short telomeres was 0.30 for dietary total antioxidant capacity (p = 0.023) and 1.37 for white bread (p = 0.025).

CONCLUSION:

It was concluded that longer telomeres were associated with higher dietary total antioxidant capacity and lower white bread consumption in Spanish children and adolescents. These findings might open a new line of investigation about the potential role of an antioxidant diet in maintaining telomere length.

KEYWORDS:

Antioxidants; Diet; Oxidative stress; Telomeres; Young population

PMID:
25131600
DOI:
10.1016/j.clnu.2014.07.015
[Indexed for MEDLINE]
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