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Int Rev Neurobiol. 2014;115:117-54. doi: 10.1016/B978-0-12-801311-3.00004-4.

Epigenetic regulatory mechanisms in stress-induced behavior.

Author information

1
Chemical Biology, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, India.
2
Epigenetics and Neuropsychiatric Disorders Laboratory, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India.
3
Epigenetics and Neuropsychiatric Disorders Laboratory, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India. Electronic address: akumar@ccmb.res.in.

Abstract

Stress response is considered to have adaptive value for organisms faced with stressful condition. Chronic stress however adversely affects the physiology and may lead to neuropsychiatric disorders. Repeated stressful events in animal models have been shown to cause long-lasting changes in neural circuitries at molecular, cellular, and physiological level, leading to disorders of mood as well as cognition. Molecular studies in recent years have implicated diverse epigenetic mechanisms, including histone modifications, DNA methylation, and noncoding RNAs, that underlie dysregulation of genes in the affected neural circuitries in chronic stress-induced pathophysiology. A review of the myriad epigenetic regulatory mechanisms associated with neural and behavioral responses in animal models of stress-induced neuropsychiatric disorders is presented here. The review also deals with clinical evidence of the epigenetic dysregulation of genes in psychiatric disorders where chronic stress appears to underlie the etiopathology.

KEYWORDS:

Chromatin remodeling; DNA methylation; Epigenetic regulatory mechanisms; Histone acetylation; Histone deacetylation; Histone demethylation; Histone methylation; Noncoding RNA; Stress-induced mood disorders

[Indexed for MEDLINE]

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