Format

Send to

Choose Destination
Gynecol Oncol. 2014 Nov;135(2):292-6. doi: 10.1016/j.ygyno.2014.08.014. Epub 2014 Aug 14.

Comparison of adenocarcinoma (ACA) and squamous cell carcinoma (SCC) of the uterine cervix in a sub-optimally screened cohort: a population-based epidemiologic study of 51,842 women in Brazil.

Author information

1
Federal University of Minas Gerais, Belo Horizonte (MG), Brazil; Clinical Epidemiology, Brazilian National Cancer Institute, Rio de Janeiro , RJ, Brazil. Electronic address: angelica.onco@uol.com.br.
2
Clinical Epidemiology, Brazilian National Cancer Institute, Rio de Janeiro , RJ, Brazil.
3
Clinical Epidemiology, Brazilian National Cancer Institute, Rio de Janeiro , RJ, Brazil; Masters Program in Rehabilitation Sciences, University Centre Augusto Motta - UNISUAM, Rio de Janeiro, RJ, Brazil.
4
Clinical Epidemiology, Brazilian National Cancer Institute, Rio de Janeiro , RJ, Brazil; Masters Program in Neuroscience, Federal University of Rio de Janeiro State, Rio de Janeiro, RJ, Brazil.

Abstract

BACKGROUND:

Most cancers of the uterine cervix are SCC, but the relative and absolute incidence of ACA has risen in recent years, and ACA now accounts for approximately 20% of invasive cervical cancers in the screened populations worldwide.

OBJECTIVE:

To compare the epidemiological, clinical characteristics, and treatment outcomes of ACA with those of SCC of the cervix in a sub-optimally screened population.

METHODS:

Data from cervical cancer patients with SCC and ACA treated from 2000 through 2009 were obtained from the Brazilian Hospital Cancer Register databases. The summary odds ratios and chi-square tests were estimated.

RESULTS:

A total of 51,842 patients including 45,540 (87.8%) cases of SCC and 6302 (12.2%) of ACA were analyzed. Compared with the ACA patients, the SCC patients were younger and more frequently black and had a higher degree of illiteracy and alcohol and tobacco consumers. The tumor stage at the time of diagnosis was also significantly different between the two groups. However, initial therapeutic response and death rate after the first course of treatment were similar in both groups.

CONCLUSIONS:

Differences between ACA and SCC were observed for all demographic and clinical variables analyzed but not for responses to treatment and death at the end of the first course of treatment. Irrespective of the histological subtype, the quality of screening and treatment must be improved in developing countries, since initial therapeutic response of ACA and SCC is similar.

KEYWORDS:

Adenocarcinoma; Brazil; Cervical cancer; Epidemiology; Squamous cell carcinoma

PMID:
25130677
DOI:
10.1016/j.ygyno.2014.08.014
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center