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Brain Res. 2014 Oct 17;1585:1-12. doi: 10.1016/j.brainres.2014.08.022. Epub 2014 Aug 15.

The protective role of prosaposin and its receptors in the nervous system.

Author information

1
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, United States.
2
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, United States. Electronic address: rhall@pharm.emory.edu.

Abstract

Prosaposin (also known as SGP-1) is an intriguing multifunctional protein that plays roles both intracellularly, as a regulator of lysosomal enzyme function, and extracellularly, as a secreted factor with neuroprotective and glioprotective effects. Following secretion, prosaposin can undergo endocytosis via an interaction with the low-density lipoprotein-related receptor 1 (LRP1). The ability of secreted prosaposin to promote protective effects in the nervous system is known to involve activation of G proteins, and the orphan G protein-coupled receptors GPR37 and GPR37L1 have recently been shown to mediate signaling induced by both prosaposin and a fragment of prosaposin known as prosaptide. In this review, we describe recent advances in our understanding of prosaposin, its receptors and their importance in the nervous system.

KEYWORDS:

GPCR; Lysosome; Myelination; Nerve; Neuroprotection; Neurotrophic

PMID:
25130661
PMCID:
PMC4529117
DOI:
10.1016/j.brainres.2014.08.022
[Indexed for MEDLINE]
Free PMC Article

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