Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biochem Mol Toxicol. 2014 Nov;28(11):515-21. doi: 10.1002/jbt.21593. Epub 2014 Aug 6.

Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid.

Author information

  • 1Department of Biochemistry, Mansoura University, Mansoura, Egypt. emyosh@yahoo.com.

Abstract

In the present study, the effect of arjunolic acid on testicular damage induced by intraperitoneal injection of rats with 7 mg/kg cisplatin was studied. Cisplatin induced a significant reduction in testicular weights, plasma testosterone, and testicular reduced glutathione levels in addition to a significant elevation of testicular malondialdehyde levels and testicular gene expressions of inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and p38 mitogen-activated protein kinase (MAPK) when compared with the control group (p < 0.05). Lower tubular diameters and depletion of germ cells and irregular small seminiferous tubules with Sertoli cells only were observed in the cisplatin group. Arjunolic acid administration significantly corrected the changes in both biochemical and histopathological parameters. Arjunolic acid plays a significant protective role against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS, TNF-α, and p38-MAPK testicular expressions.

KEYWORDS:

Arjunolic Acid; Cisplatin; Oxidative Stress; Rat; Testis; Toxicity

PMID:
25130312
DOI:
10.1002/jbt.21593
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center