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Cancer Lett. 2014 Oct 28;353(2):153-9. doi: 10.1016/j.canlet.2014.06.022. Epub 2014 Aug 14.

Enriched CD44(+)/CD24(-) population drives the aggressive phenotypes presented in triple-negative breast cancer (TNBC).

Author information

1
Department of Medical Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
2
Shandong Cancer Hospital/Institute, Jinan, Shandong 250017, China.
3
State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
4
State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: qianhaili@gmail.com.
5
Department of Medical Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: binghxu@gmail.com.

Abstract

The mechanism underlying the aggressive behaviors of triple negative breast cancer (TNBC) is not well characterized yet. The association between cancer stem cell (CSC) population and the aggressive behaviors of TNBC has not been established. We found the CD44(+)/CD24(-) cell population was enriched in TNBC tissues and cell lines, with a higher capacity of proliferation, migration, invasion and tumorigenicity as well as lower adhesion ability. The CD44(+)/CD24(-) cell population with cancer stem cell-like properties may play an important role in the aggressive behaviors of TNBC. This discovery may lead to new therapeutic strategies targeting CD44(+)/CD24(-) cell population in TNBC.

KEYWORDS:

CD44(+)/CD24(−).; Cancer stem cells; Triple negative breast cancer

PMID:
25130168
DOI:
10.1016/j.canlet.2014.06.022
[Indexed for MEDLINE]

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