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J Pediatr. 2014 Nov;165(5):1046-9.e1-2. doi: 10.1016/j.jpeds.2014.07.007. Epub 2014 Aug 14.

Physical activity modifies the associations between genetic variants and blood pressure in European adolescents.

Author information

1
Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil; GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain. Electronic address: augustocesar.demoraes@usp.br.
2
GENUD (Growth, Exercise, Nutrition, and Development) Research Group, Universidad de Zaragoza, Zaragoza, Spain; Faculty of Health Sciences of the University of Zaragoza, Zaragoza, Spain.
3
Department of Preventive Medicine, School of Medicine of the University of São Paulo, São Paulo, SP, Brazil.
4
INSERM, U744, Institut Pasteur de Lille, Univ Lille Nord de France; UDSL, Lille, France.
5
Preventive Medicine and Nutrition Unit, University of Crete School of Medicine, Heraklion, Crete, Greece.
6
Immunonutrition Research Group, Department of Metabolism and Nutrition, Food Science and Technology and Nutrition Institute, Spanish National Research Council, Madrid, Spain.
7
Department of Pediatrics, Medical Faculty, University of Pécs, Pécs, Hungary.
8
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
9
Promoting Fitness and Health through Physical Activity Research Group, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
10
Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
11
Department of Pediatrics, Private Medical University Salzburg, Salzburg, Austria.
12
Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
13
Institut für Ernährungs-und Lebensmittelwissenschaften-Humanernährung, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany; Department of Health and Human Performance, Faculty of Physical Activity and Sport-INEF, Technical University of Madrid, Madrid, Spain.

Erratum in

  • J Pediatr. 2014 Dec;165(6):1276-7.

Abstract

We hypothesized that physical activity and sedentary behavior could modify the associations between known genetic variants blood pressure-associated genes in European adolescents. Meeting current physical activity recommendations (≥ 60 minutes/day) was able attenuate the deleterious effect of the NOS3 rs3918227 polymorphism on systolic blood pressure in European adolescents.

PMID:
25129643
DOI:
10.1016/j.jpeds.2014.07.007
[Indexed for MEDLINE]

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