Abstract
This retrospective study was designed to investigate the relationship between the expression of IL-10, CD4, CD8, and FOXP3 and clinicopathological features and prognosis in breast cancer patients. The expression of IL-10, CD4, CD8, and FOXP3 was detected by immunohistochemistry. Staining intensity of only IL-10 was associated with disease-free survival and distance disease-free survival (P<0.05). Staining density of IL-10 in stromal cells was associated with overall survival and distance disease-free survival (P<0.05). IL-10 expression levels might be used as a prognostic indicator for the recurrence, metastasis, and survival of breast cancer patients.
MeSH terms
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Adenocarcinoma, Mucinous / metabolism
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Adenocarcinoma, Mucinous / mortality
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Adenocarcinoma, Mucinous / secondary
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Adult
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / metabolism*
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Breast Neoplasms / metabolism*
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Breast Neoplasms / mortality
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Breast Neoplasms / pathology
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CD4 Antigens / metabolism
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CD8 Antigens / metabolism
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Carcinoma, Ductal, Breast / metabolism
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Carcinoma, Ductal, Breast / mortality
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Carcinoma, Ductal, Breast / secondary
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Carcinoma, Lobular / metabolism
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Carcinoma, Lobular / mortality
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Carcinoma, Lobular / secondary
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Carcinoma, Medullary / metabolism
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Carcinoma, Medullary / mortality
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Carcinoma, Medullary / secondary
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Carcinoma, Papillary / metabolism
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Carcinoma, Papillary / mortality
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Carcinoma, Papillary / secondary
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Female
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Follow-Up Studies
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Forkhead Transcription Factors / metabolism
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Humans
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Immunoenzyme Techniques
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Interleukin-10 / metabolism*
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Lymphatic Metastasis
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Middle Aged
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Neoplasm Invasiveness
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Neoplasm Recurrence, Local / metabolism*
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Neoplasm Recurrence, Local / mortality
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Neoplasm Recurrence, Local / pathology
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Neoplasm Staging
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Prognosis
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Retrospective Studies
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Survival Rate
Substances
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Biomarkers, Tumor
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CD4 Antigens
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CD8 Antigens
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FOXP3 protein, human
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Forkhead Transcription Factors
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IL10 protein, human
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Interleukin-10