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Vet Microbiol. 2014 Sep 17;173(1-2):136-40. doi: 10.1016/j.vetmic.2014.07.012. Epub 2014 Jul 29.

Detection of a pneumonia virus of mice (PVM) in an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS).

Author information

1
Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan. Electronic address: madarame@azabu-u.ac.jp.
2
Laboratory of Pathology, Department of Environmental Hygine, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
3
Laboratory of Small Animal Clinics, Veterinary Teaching Hospital, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.
4
Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Fuchu 183-8509, Tokyo, Japan.
5
Research Institute of Biosciences, Azabu University, 1-17-71, Fuchinobe, Chuo, Sagamihara 252-5201, Kanagawa, Japan.

Abstract

A pneumonia virus of mice (PVM) from an African hedgehog (Atelerix arbiventris) with suspected wobbly hedgehog syndrome (WHS) was detected and genetically characterized. The affected hedgehog had a nonsuppurative encephalitis with vacuolization of the white matter, and the brain samples yielded RNA reads highly homogeneous to PVM strain 15 (96.5% of full genomic sequence homology by analysis of next generation sequencing). PVM antigen was also detected in the brain and the lungs immunohistochemically. A PVM was strongly suggested as a causative agent of encephalitis of a hedgehog with suspected WHS. This is a first report of PVM infection in hedgehogs.

KEYWORDS:

African hedgehog (Atelerix arbiventris); Encephalitis; Pneumonia virus of mice (PVM)

PMID:
25129384
DOI:
10.1016/j.vetmic.2014.07.012
[Indexed for MEDLINE]

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