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Indian Pediatr. 2014 Aug;51(8):651-3.

Clinical profile of scrub typhus in children and its association with hemophagocytic lymphohistiocytosis.

Author information

1
Department of Pediatrics, PGIMER, Chandigarh; and *Department of Microbiology, Indira Gandhi Medical College, Shimla, India. Correspondence to: Prof. Sunit C Singhi, Professor and Head, Department of Pediatrics, Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research, Chandigarh 160 012, India. sunit.singhi@gmail.com.

Abstract

OBJECTIVE:

To study the clinical profile of children with scrub typhus and its association with hemophagocytic lymphohistiocytosis.

METHODS:

Children presenting with unexplained fever and multi-systemic involvement between May to December 2011 were tested for scrub typhus using IgM ELISA kits. Occurrence of Hemophagocytic lymphohistiocytosis in IgM positive cases of scrub typhus was studied.

RESULTS:

Of the 35 children with unexplained fever and multi-systemic involvement, 15 children (9 boys) tested positive for scrub typhus. Thrombocytopenia, hypoalbuminemia and raised hepatic transaminases were observed in all children. Out of seven children evaluated for hemophagocytic lymphohistiocytosis. 3 met the criteria for hemophagocytosis. Two children (one with hemophagocytic lymphohistiocytosis) died.

CONCLUSIONS:

Scrub typhus is a common cause of unexplained fever in children in northern India. Hemophagocytic lymphohistiocytosis can occasionally complicate scrub typhus in children.

PMID:
25129000
[Indexed for MEDLINE]
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