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FEBS Lett. 2014 Nov 17;588(22):4140-7. doi: 10.1016/j.febslet.2014.08.002. Epub 2014 Aug 12.

MicroRNAs in the interaction between host and bacterial pathogens.

Author information

1
Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany.
2
International Centre for Genetic Engineering and Biotechnology (ICGEB), 34149 Trieste, Italy; UC-BIOTECH, Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3004-504 Coimbra, Portugal.
3
Institute for Molecular Infection Biology (IMIB), University of Würzburg, 97080 Würzburg, Germany. Electronic address: ana.eulalio@uni-wuerzburg.de.

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.

KEYWORDS:

Bacterial pathogens; Gut microbiota; Host response; MicroRNAs

PMID:
25128459
DOI:
10.1016/j.febslet.2014.08.002
[Indexed for MEDLINE]
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