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Fitoterapia. 2014 Oct;98:209-14. doi: 10.1016/j.fitote.2014.08.011. Epub 2014 Aug 12.

Penialidins A-C with strong antibacterial activities from Penicillium sp., an endophytic fungus harboring leaves of Garcinia nobilis.

Author information

1
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany; Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
2
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
3
Julius Kühn Institute, Federal Research Centre for Cultivated Plants, Institute for National and International Plant Health, Messeweg 11-12, D-38104 Braunschweig, Germany.
4
Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon.
5
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.

Abstract

Three new polyketides named penialidins A-C (1-3), along with one known compound, citromycetin (4), were isolated from an endophytic fungus, Penicillium sp., harbored in the leaves of the Cameroonian medicinal plant Garcinia nobilis. Their structures were elucidated by means of spectroscopic and spectrometric methods (NMR and HRMS(n)). The antibacterial efficacies of the new compounds (1-3) were tested against the clinically-important risk group 2 (RG2) bacterial strains of Staphylococcus aureus and Escherichia coli. The ecologically imposing strains of E. coli (RG1), Bacillus subtilis and Acinetobacter sp. BD4 were also included in the assay. Compound 3 exhibited pronounced activity against the clinically-relevant S. aureus as well as against B. subtilis comparable to that of the reference standard (streptomycin). Compound 2 was also highly-active against S. aureus. By comparing the structures of the three new compounds (1-3), it was revealed that altering the substitutions at C-10 and C-2 can significantly increase the antibacterial activity of 1.

KEYWORDS:

Antibacterial; Endophytic fungus; Garcinia nobilis; Penicillium sp.; Polyketides

PMID:
25128427
DOI:
10.1016/j.fitote.2014.08.011
[Indexed for MEDLINE]

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