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Int J Med Microbiol. 2014 Oct;304(7):858-67. doi: 10.1016/j.ijmm.2014.07.006. Epub 2014 Jul 25.

Facts, myths and hypotheses on the zoonotic nature of Mycobacterium avium subspecies paratuberculosis.

Author information

1
Medical Clinic 1, University of Erlangen-Nuermberg, Ulmenweg 18, D-91054 Erlangen, Germany.
2
Institute of Veterinary Food Science, Faculty of Veterinary Medicine, Justus Liebig University, Frankfurter Straße 92, 35392 Gießen, Germany.
3
IVD GmbH, Heisterbergallee 12, 30453 Hannover, Germany.
4
Institute for Microbiology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany. Electronic address: ralph.goethe@tiho-hannover.de.
5
Department of Microbiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.
6
Institute of Molecular Pathogenesis, Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Naumburger Str. 96a, 07743 Jena, Germany.
7
Institute for Microbiology, Department of Infectious Diseases, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
8
Justus-Liebig-University Giessen, Department of Gastroenterology, Klinikstr.33, 35392 Giessen, Germany.
9
Helmholtz Centre for Infection Research, Molecular Immunology, Inhoffenstraße 7, 38124 Braunschweig, Germany.

Abstract

Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of paratuberculosis (Johne's disease [JD]), a chronic granulomatous enteritis in ruminants. JD is one of the most widespread bacterial diseases of domestic animals with significant economic impact. The histopathological picture of JD resembles that of Crohn's disease (CD), a human chronic inflammatory bowel disease of still unresolved aetiology. An aetiological relevance of MAP for CD has been proposed. This and the ambiguity of other published epidemiological findings raise the question whether MAP represents a zoonotic agent. In this review, we will discuss evidence that MAP has zoonotic capacity.

KEYWORDS:

Crohn's disease; Johne's disease; Mycobacterium avium; Paratuberculosis; Zoonosis.

PMID:
25128370
DOI:
10.1016/j.ijmm.2014.07.006
[Indexed for MEDLINE]

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