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J Neurosci Methods. 2015 Jul 30;250:85-93. doi: 10.1016/j.jneumeth.2014.08.003. Epub 2014 Aug 13.

Cluster-based computational methods for mass univariate analyses of event-related brain potentials/fields: A simulation study.

Author information

1
Centre for Clinical Brain Sciences, Neuroimaging Sciences, University of Edinburgh, Edinburgh, UK. Electronic address: cyril.pernet@ed.ac.uk.
2
Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, 13385 Marseille, France.
3
Department of Statistics, Warwick University, Coventry, UK.
4
Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.

Abstract

BACKGROUND:

In recent years, analyses of event related potentials/fields have moved from the selection of a few components and peaks to a mass-univariate approach in which the whole data space is analyzed. Such extensive testing increases the number of false positives and correction for multiple comparisons is needed.

METHOD:

Here we review all cluster-based correction for multiple comparison methods (cluster-height, cluster-size, cluster-mass, and threshold free cluster enhancement - TFCE), in conjunction with two computational approaches (permutation and bootstrap).

RESULTS:

Data driven Monte-Carlo simulations comparing two conditions within subjects (two sample Student's t-test) showed that, on average, all cluster-based methods using permutation or bootstrap alike control well the family-wise error rate (FWER), with a few caveats.

CONCLUSIONS:

(i) A minimum of 800 iterations are necessary to obtain stable results; (ii) below 50 trials, bootstrap methods are too conservative; (iii) for low critical family-wise error rates (e.g. p=1%), permutations can be too liberal; (iv) TFCE controls best the type 1 error rate with an attenuated extent parameter (i.e. power<1).

KEYWORDS:

Cluster-based statistics; ERP; Family-wise error rate; Monte-Carlo simulations; Multiple comparison correction; Threshold free cluster enhancement

PMID:
25128255
PMCID:
PMC4510917
DOI:
10.1016/j.jneumeth.2014.08.003
[Indexed for MEDLINE]
Free PMC Article

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