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PLoS One. 2014 Aug 15;9(7):e104857. doi: 10.1371/journal.pone.0104857. eCollection 2014.

Treatment of FANCA cells with resveratrol and N-acetylcysteine: a comparative study.

Author information

1
SC Laboratory of Musculoskeletal Cell Biology, IOR, Bologna, Italy.
2
DIFAR-Biochemistry Lab., University of Genova, Genova, Italy.
3
CNR-National Research Council of Italy, Institute of Molecular Genetics, Unit of Bologna-IOR, Bologna, Italy.
4
S. C. Mutagenesis, IRCCS AOU San Martino - IST (Istituto Nazionale per la Ricerca sul Cancro), Genova, Italy.
5
Centro di Diagnostica Genetica e Biochimica delle Malattie Metaboliche, Istituto Giannina Gaslini, Genova, Italy.
6
Hematology Unit, Istituto Giannina Gaslini, Genova, Italy.

Abstract

Fanconi anemia (FA) is a genetic disorder characterised by chromosome instability, cytokine ipersensibility, bone marrow failure and abnormal haematopoiesis associated with acute myelogenous leukemia. Recent reports are contributing to characterize the peculiar FA metabolism. Central to these considerations appears that cells from complementation group A (FANCA) display an altered red-ox metabolism. Consequently the possibility to improve FA phenotypical conditions with antioxidants is considered. We have characterized from the structural and biochemical point of view the response of FANCA lymphocytes to N-acetyl-cysteine (NAC) and resveratrol (RV). Surprisingly both NAC and RV failed to revert all the characteristic of FA phenotype and moreover their effects are not super imposable. Our data suggest that we must be aware of the biological effects coming from antioxidant treatment.

PMID:
25126945
PMCID:
PMC4134242
DOI:
10.1371/journal.pone.0104857
[Indexed for MEDLINE]
Free PMC Article

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