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Food Chem Toxicol. 2015 May;79:13-31. doi: 10.1016/j.fct.2014.08.004. Epub 2014 Aug 12.

Cumulative dietary exposure to a selected group of pesticides of the triazole group in different European countries according to the EFSA guidance on probabilistic modelling.

Author information

1
National Institute for Public Health and the Environment (RIVM), Box 1, NL-3720 BA Bilthoven, The Netherlands. Electronic address: polly.boon@rivm.nl.
2
National Institute for Public Health and the Environment (RIVM), Box 1, NL-3720 BA Bilthoven, The Netherlands. Electronic address: gerda.van.donkersgoed@rivm.nl.
3
Ministry of Health, State General Laboratory, 44 Kimonos Street, 1451 Nicosia, Cyprus. Electronic address: dchristodoulou@sgl.moh.gov.cy.
4
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 27-31 avenue du Général Leclerc, 94701 Maisons-Alfort Cedex, France. Electronic address: amelie.crepet@anses.fr.
5
Consiglio per la Ricerca e la sperimentazione in Agricoltura - Centro di ricerca per gli alimenti e la NUTrizione (Agricultural Research Council - Research Centre for Food and Nutrition) (CRA-NUT), via Ardeatina, 546, 00178 Rome, Italy.
6
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 27-31 avenue du Général Leclerc, 94701 Maisons-Alfort Cedex, France. Electronic address: Virginie.desvignes@anses.fr.
7
National Food Agency, Risk Benefit Assessment Department, Box 622, 751 26 Uppsala, Sweden. Electronic address: b-g.ericsson@slv.se.
8
ICPS - International Centre for Pesticides and Health Risk Prevention, AO "Luigi Sacco", Polo Universitario, Padiglione 17, Via G.B. Grassi, 74 Milan Hospital, Milan, Italy. Electronic address: francesco.galimberti@icps.it.
9
Ministry of Health, State General Laboratory, 44 Kimonos Street, 1451 Nicosia, Cyprus. Electronic address: elkakour@spidernet.com.cy.
10
National Food Institute, Technical University of Denmark, Department of Food Chemistry, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark. Electronic address: bhje@food.dtu.dk.
11
National Institute of Public Health in Prague, Center for Health, Nutrition and Food, Palackého 3a, 61242 Brno, Czech Republic. Electronic address: rehurkova@chpr.szu.cz.
12
French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Risk Assessment Department, 27-31 avenue du Général Leclerc, 94701 Maisons-Alfort Cedex, France. Electronic address: josselin.rety@anses.fr.
13
National Institute of Public Health in Prague, Center for Health, Nutrition and Food, Palackého 3a, 61242 Brno, Czech Republic. Electronic address: jruprich@chpr.szu.cz.
14
National Food Agency, Risk Benefit Assessment Department, Box 622, 751 26 Uppsala, Sweden. Electronic address: salomon.sand@slv.se.
15
Health and Safety Executive, Chemicals Regulation Directorate, Mallard House, Kings Pool, 3 Peasholme Green, York YO1 7PX, UK. Electronic address: cstephenson@exponent.com.
16
National Food Agency, Risk Benefit Assessment Department, Box 622, 751 26 Uppsala, Sweden. Electronic address: anita.stromberg@slv.se.
17
Consiglio per la Ricerca e la sperimentazione in Agricoltura - Centro di ricerca per gli alimenti e la NUTrizione (Agricultural Research Council - Research Centre for Food and Nutrition) (CRA-NUT), via Ardeatina, 546, 00178 Rome, Italy. Electronic address: aida.turrini@entecra.it.
18
Biometris, Wageningen University and Research Centre, P.O. Box 16, 6700 AA Wageningen, The Netherlands. Electronic address: hilko.vandervoer@wur.nl.
19
Ministry of Health, State General Laboratory, 44 Kimonos Street, 1451 Nicosia, Cyprus. Electronic address: pziegler@sgl.moh.gov.cy.
20
Health and Safety Executive, Chemicals Regulation Directorate, Mallard House, Kings Pool, 3 Peasholme Green, York YO1 7PX, UK. Electronic address: paul.hamey@hse.gsi.gov.uk.
21
National Institute for Public Health and the Environment (RIVM), Box 1, NL-3720 BA Bilthoven, The Netherlands. Electronic address: jacob.van.klaveren@rivm.nl.

Abstract

The practicality was examined of performing a cumulative dietary exposure assessment according to the requirements of the EFSA guidance on probabilistic modelling. For this the acute and chronic cumulative exposure to triazole pesticides was estimated using national food consumption and monitoring data of eight European countries. Both the acute and chronic cumulative dietary exposures were calculated according to two model runs (optimistic and pessimistic) as recommended in the EFSA guidance. The exposures obtained with these model runs differed substantially for all countries, with the highest exposures obtained with the pessimistic model run. In this model run, animal commodities including cattle milk and different meat types, entered in the exposure calculations at the level of the maximum residue limit (MRL), contributed most to the exposure. We conclude that application of the optimistic model run on a routine basis for cumulative assessments is feasible. The pessimistic model run is laborious and the exposure results could be too far from reality. More experience with this approach is needed to stimulate the discussion of the feasibility of all the requirements, especially the inclusion of MRLs of animal commodities which seem to result in unrealistic conclusions regarding their contribution to the dietary exposure.

KEYWORDS:

Acute exposure; Chronic exposure; Cumulative Assessment Group; Cumulative dietary exposure; EFSA; Probabilistic modelling

PMID:
25125392
DOI:
10.1016/j.fct.2014.08.004
[Indexed for MEDLINE]

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