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Metabolism. 2014 Oct;63(10):1257-64. doi: 10.1016/j.metabol.2014.07.007. Epub 2014 Jul 18.

Effects of a eucaloric reduced-carbohydrate diet on body composition and fat distribution in women with PCOS.

Author information

1
Department of Nutrition Sciences, Georgia Regents University, Augusta, GA. Electronic address: amymiski@uab.edu.
2
Department of Nutrition Sciences, Georgia Regents University, Augusta, GA.
3
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Georgia Regents University, Augusta, GA.
4
Department of Obstetrics & Gynecology, Georgia Regents University, Augusta, GA; Department of Medicine, Georgia Regents University, Augusta, GA.
5
Department of Medicine, Division of Preventive Medicine, Georgia Regents University, Augusta, GA.
6
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Georgia Regents University, Augusta, GA.

Abstract

OBJECTIVE:

To determine if consumption of a reduced-carbohydrate (CHO) diet would result in preferential loss of adipose tissue under eucaloric conditions, and whether changes in adiposity were associated with changes in postprandial insulin concentration.

METHODS:

In a crossover-diet intervention, 30 women with PCOS consumed a reduced-CHO diet (41:19:40% energy from CHO:protein:fat) for 8 weeks and a standard diet (55:18:27) for 8 weeks. Body composition by DXA and fat distribution by CT were assessed at baseline and following each diet phase. Insulin AUC was obtained from a solid meal test (SMT) during each diet phase.

RESULTS:

Participants lost 3.7% and 2.2% total fat following the reduced-CHO diet and STD diet, resp. (p<0.05 for difference between diets). The reduced-CHO diet induced a decrease in subcutaneous-abdominal, intra-abdominal, and thigh-intermuscular adipose tissue (-7.1%, -4.6%, and -11.5%, resp.), and the STD diet induced a decrease in total lean mass. Loss of fat mass following the reduced CHO diet arm was associated with lower insulin AUC (p<0.05) during the SMT.

CONCLUSIONS:

In women with PCOS, consumption of a diet lower in CHO resulted in preferential loss of fat mass from metabolically harmful adipose depots, whereas a diet high in CHO appeared to promote repartitioning of lean mass to fat mass.

KEYWORDS:

Intra-abdominal adipose tissue; Macronutrient composition; Obesity

PMID:
25125349
PMCID:
PMC4191914
DOI:
10.1016/j.metabol.2014.07.007
[Indexed for MEDLINE]
Free PMC Article

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