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JAMA Ophthalmol. 2014 Nov;132(11):1334-40. doi: 10.1001/jamaophthalmol.2014.2854.

Prevalence of and risk factors for diabetic macular edema in the United States.

Author information

1
USC Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles.
2
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland3Editor, JAMA Ophthalmology.
3
Outcomes Insights, Inc, Westlake Village, California.
4
Division of Epidemiology, The Ohio State University College of Public Health, Columbus.
5
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
6
Genentech, Inc, South San Francisco, California.

Abstract

IMPORTANCE:

Diabetic macular edema (DME) is a leading cause of vision loss in persons with diabetes mellitus. Although there are national estimates for the prevalence of diabetic retinopathy and its risk factors among persons with diabetes, to our knowledge, no comparable estimates are available for DME specifically.

OBJECTIVES:

To estimate the prevalence of DME in the US population and to identify associated risk factors.

DESIGN, SETTING, AND PARTICIPANTS:

A cross-sectional analysis of 1038 participants aged 40 years or older with diabetes and valid fundus photographs in the 2005 to 2008 National Health and Nutrition Examination Survey.

MAIN OUTCOMES AND MEASURES:

The overall prevalence of DME and its prevalence according to age, race/ethnicity, and sex.

RESULTS:

Of the 1038 persons with diabetes analyzed for this study, 55 had DME, for an overall weighted prevalence of 3.8% (95% CI, 2.7%-4.9%) or approximately 746, 000 persons in the US 2010 population aged 40 years or older. We identified no differences in the prevalence of DME by age or sex. Multivariable logistic regression analysis showed that the odds of having DME were higher for non-Hispanic blacks than for non-Hispanic whites (odds ratio [OR], 2.64; 95% CI, 1.19-5.84; P = .02). Elevated levels of glycosylated hemoglobin A1c (OR, 1.47; 95% CI, 1.26-1.71 for each 1%; P < .001) and longer duration of diabetes (OR, 8.51; 95% CI, 3.70-19.54 for ≥ 10 vs <10 years; P < .001) were also associated with DME prevalence.

CONCLUSIONS AND RELEVANCE:

These results suggest a greater burden of DME among non-Hispanic blacks, individuals with high levels of hemoglobin A1c, and those with longer duration of diabetes. Given recent treatment advances in reducing vision loss and preserving vision in persons with DME, it is imperative that all persons with diabetes receive early screening; this recommendation is even more important for those at higher risk for DME.

PMID:
25125075
PMCID:
PMC4576994
DOI:
10.1001/jamaophthalmol.2014.2854
[Indexed for MEDLINE]
Free PMC Article

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