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Rev Peru Med Exp Salud Publica. 2014 Apr;31(2):261-6.

[Effect of extracts of Geranium ayavacense W. (Pasuchaca) on glycemia on rats with experimental diabetes mellitus].

[Article in Spanish]

Author information

1
Instituto de Medicina Tradicional, Seguro Social de Salud, Iquitos, PerĂș

Abstract

OBJECTIVES:

To determine if the lyophilized aqueous extract of Geranium ayavacense (Pasuchaca) has any effect on glycemia in rats with experimental diabetes mellitus.

MATERIALS AND METHODS:

Experimental diabetes was induced with alloxan. Rats included in the study met the following criteria: glycemia greater than 200 mg/dL post administration of alloxan, and with a weight greater than 200 g. Rats with experimental diabetes were divided into six groups of eight rats each. Group I received 3 mL of distilled water (control); group II received Geranium ayavacense 12.7 mg/kg; group III received Geranium ayavacense 100 mg/kg; group IV received Geranium ayavacense 200 mg/kg; group V received Geranium ayavacense 300 mg/kg; group VI received Geranium ayavacense 500 mg/kg. Basal glycemia was determined. Glycemia evaluations were performed at the 1st, 3rd, 6th, 12th and 24th hour after administrating the different interventions.

RESULTS:

Geranium ayavacense groups of 300 and 500 mg/kg decreased glycemia significantly (p <0.01) in every hour assessed after administration of the extract, when compared with the control group. Geranium ayavacense group of 300 mg/kg decreased their blood glucose 8.14; 10.68; 14.87; 19.36 and 23.7% in the 1st, 3rd, 6th, 12th and 24th hour respectively.

CONCLUSIONS:

Under experimental conditions, the aqueous extract of Geranium ayavacense has hypoglycemic effects in rats.

PMID:
25123863
[Indexed for MEDLINE]
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