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Prostaglandins Leukot Essent Fatty Acids. 2014 Oct;91(4):141-8. doi: 10.1016/j.plefa.2014.07.012. Epub 2014 Jul 22.

A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols in adults with mild-to-moderate hypertriglyceridemia.

Author information

1
Biofortis Clinical Research, Addison, IL, United States. Electronic address: kmaki@mc-mcr.com.
2
DSM Nutritional Products, Columbia, MD, United States.
3
Biofortis Clinical Research, Addison, IL, United States.
4
Evanston Premier Healthcare Research, Evanston, IL, United States.

Abstract

In this double-blind, parallel trial, 93 healthy adults with hypertriglyceridemia (triacylglycerols [TAG] 150-499 mg/dL) were randomized to receive either a nutritional oil derived from marine algae (DHA-O; 2.4 g/day docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA] in a 2.7:1 ratio), fish oil (FO; 2.0 g/day DHA and EPA in a 0.7:1 ratio), or a corn oil/soy oil control as 4-1g softgel capsules/day with meals for 14 weeks; and were instructed to maintain their habitual diet. Percent changes from baseline for DHA-O, FO, and control, respectively, were TAG (-18.9, -22.9, 3.5; p<0.001 DHA-O and FO vs. control), low-density lipoprotein cholesterol (4.6, 6.8, -0.6; p<0.05 DHA-O and FO vs. control), and high-density lipoprotein cholesterol (4.3, 6.9, 0.6; p<0.05 FO vs. control). This study demonstrated that ingestion of microalgal DHA-O providing 2.4 g/day DHA+EPA lowered TAG levels to a degree that was not different from that of a standard fish oil product, and that was significantly more than for a corn oil/soy oil control.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01737099.

KEYWORDS:

DHA; EPA; Lipids; Omega-3; Triacylglycerols; Triglycerides

PMID:
25123060
DOI:
10.1016/j.plefa.2014.07.012
[Indexed for MEDLINE]

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