Format

Send to

Choose Destination
Cell Host Microbe. 2014 Aug 13;16(2):150-152. doi: 10.1016/j.chom.2014.07.013.

How a virus blocks a cellular emergency access lane to the nucleus, STAT!

Author information

1
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: mdaugher@fhcrc.org.
2
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Abstract

Early in viral infection, the STAT1 transcription factor is rapidly transported into the nucleus using a nonconventional import mechanism to establish an antiviral state. In this issue, Xu et al. (2014) show how the Ebola virus VP24 protein precisely blocks specialized STAT1 import while leaving other cellular import processes intact.

PMID:
25121743
DOI:
10.1016/j.chom.2014.07.013
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center