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Cell Host Microbe. 2014 Aug 13;16(2):143-145. doi: 10.1016/j.chom.2014.07.011.

Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

Author information

1
Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27516, USA. Electronic address: scott_bultman@med.unc.edu.
2
Department of Infectious Diseases & Pathology, Department of Medicine, University of Florida, Gainesville, FL 32611, USA. Electronic address: christian.jobin@medicine.ufl.edu.

Abstract

Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cells, suggesting that it can act as an oncometabolite.

PMID:
25121740
PMCID:
PMC4179296
DOI:
10.1016/j.chom.2014.07.011
[Indexed for MEDLINE]
Free PMC Article

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