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Ocul Immunol Inflamm. 2016;24(2):147-52. doi: 10.3109/09273948.2014.943349. Epub 2014 Aug 14.

Clinical Manifestations and Outcomes of Syphilis-associated Uveitis in Northern Spain.

Author information

1
a Department of Ophthalmology , BioCruces Health Research Institute, Cruces Hospital, Grupo Oftalmobiología Experimental (GOBE), University of the Basque Country , Bilbao , Spain .
2
b Department of Clinical Epidemiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
3
c Department of Internal Medicine , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
4
d Department of Infectious Diseases , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
5
e Department of Microbiology , BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country , Bilbao , Spain .
6
f Department of Ophthalmology , Hospital de Vigo , Spain .
7
g Department of Ophthalmology , Hospital Clinico San Carlos , Madrid , Spain .
8
h Department of Rheumatology , Hospital Marques de Valdecilla , Santander , Spain .
9
i Department of Ophthalmology , Hospital Clinic i Provincial , Barcelona , Spain .
10
j Department of Ophthalmology , Hospital de Leon , Spain .
11
k Department of Ophthalmology Hospital Universitari Vall d'Hebron , Universitat Autonoma de Barcelona , Barcelona , Spain , and.
12
l Department of Ophthalmology , Hospital Donostia , Spain.

Abstract

PURPOSE:

To describe the clinical characteristics and to assess visual prognosis of patients with syphilis-associated uveitis in northern Spain.

METHODS:

Retrospective review of clinical records in eight general uveitis referral centers.

RESULTS:

Since the year 2000, 50 patients have been diagnosed: 31 men and 19 women; median age was 41 (19-76) years. A total of 34% were co-infected with HIV and 24% presented systemic manifestations of syphilis. Median initial visual acuity and vision at last visit in 93 affected eyes was 20/50 (20/20-20/2000) and 20/22 (20/20-20/2000), respectively (p < .0001). The most frequent manifestation was papillitis (33.3%). Fifty percent of eyes with macular edema on admission presented worsening of visual acuity at last visit, whereas frequency of worsening in eyes without edema was 7.1% (p = 0.009).

CONCLUSIONS:

In our series, patients with syphilitic uveitis were more usually middle-aged men and were frequently co-infected with HIV. Although most patients showed posterior segment involvement, visual prognosis was good.

KEYWORDS:

HIV; MSM; Treponema pallidum; syphilis; uveitis

PMID:
25121345
DOI:
10.3109/09273948.2014.943349
[Indexed for MEDLINE]

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