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J Korean Med Sci. 2014 Aug;29(8):1090-3. doi: 10.3346/jkms.2014.29.8.1090. Epub 2014 Jul 30.

Follow-up testing of interferon-gamma release assays are useful in ankylosing spondylitis patients receiving anti-tumor necrosis factor alpha for latent tuberculosis infection.

Author information

1
Division of Rheumatology, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.
2
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.
3
Department of Orthopaedic Surgery, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea.

Abstract

We evaluated the utility of follow-up interferon-gamma release assays (IGRAs) for the diagnosis of reactivation of latent tuberculosis infection (LTBI) or new tuberculosis in ankylosing spondylitis (AS) patients receiving anti-tumor necrosis factor alpha (anti-TNFα). The study participants (n=127) had a negative IGRA screening before receiving anti-TNFα and were evaluated by follow-up IGRA. We retrospectively examined data of the subjects according to age, gender, tuberculosis prophylaxis, concomitant medications, IGRA conversion and anti-TNFα, including type and treatment duration. The median duration of anti-TNFα was 21.5 months, and the median age was 35.3 yr. Of the 127 patients, IGRA conversion was found in 10 patients (7.9%). There was no significant variation between IGRA conversion rate and any risk factors except for age. IGRA conversion rate was not significantly different between AS and rheumatoid arthritis (P=0.12). IGRA conversion was observed in AS patients receiving anti-TNFα in Korea. A follow-up IGRA test can be helpful for identifying LTBI or new tuberculosis in AS patients receiving anti-TNFα.

KEYWORDS:

Ankylosing Spondylitis; Anti-Tumor Necrosis Factor; Interferon-Gamma Release Assay; Latent Tuberculosis Infection

PMID:
25120318
PMCID:
PMC4129200
DOI:
10.3346/jkms.2014.29.8.1090
[Indexed for MEDLINE]
Free PMC Article
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