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Inflammation. 2015 Apr;38(2):606-15. doi: 10.1007/s10753-014-9967-1.

Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats.

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Graduate Program in Biological Science: Toxicological Biochemistry, Department of Pharmacology, Federal University of Santa Maria (UFSM), Avenida Roraima 1000, Camobi, CEP 97105-900, Santa Maria, RS, Brazil,


Vitamin E (vit-E) is a lipophilic antioxidant, and its anti-inflammatory activity is still not full characterized. Thus, our goal was to investigate the anti-inflammatory effect of repeated vit-E treatment in the arthritis induced by the intraplantar injection of complete Freund's adjuvant (CFA). We observed an increase in arthritis scores, interleukin-1β and H2O2 levels, neutrophil and macrophage infiltration, thermal hyperalgesia, mechanical allodynia, and loss of function induced by intraplantar CFA injection. These effects were unaltered after 1 day, partially reversed after 3 days, and inhibited after 9 days after vit-E treatment. Furthermore, the concentration of vit-E was reduced and that of tumor necrosis factor-alpha was increased in the CFA-injected paw. Both effects were reversed from 1 to 9 days after vit-E treatment. However, vit-E treatment did not alter CFA-induced edema at any time. Thus, vit-E treatment produced an anti-inflammatory effect of slow onset in CFA, which demonstrates a disease-modifying drug profile.

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