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Indian J Pediatr. 2015 Mar;82(3):221-4. doi: 10.1007/s12098-014-1548-7. Epub 2014 Aug 15.

Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year.

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Department of Pediatrics, The First Affiliated Hospital of College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, China.



To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y.


A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry.


Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06-51.78) (pā€‰=ā€‰0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew.


This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.

[Indexed for MEDLINE]

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