Format

Send to

Choose Destination
See comment in PubMed Commons below
PLoS One. 2014 Aug 13;9(8):e104521. doi: 10.1371/journal.pone.0104521. eCollection 2014.

Statin therapy is associated with improved survival in patients with non-serous-papillary epithelial ovarian cancer: a retrospective cohort analysis.

Author information

1
Department of Obstetrics & Gynecology/Section of Gynecologic Oncology - Center for Integrative Science, University of Chicago, Chicago, Illinois, United States of America.
2
Department of Health Studies, University of Chicago, Chicago, Illinois, United States of America.
3
Department of Pharmaceutical Sciences, Chicago State University, Chicago, Illinois, United States of America.

Abstract

AIM:

To determine whether statin use is associated with improved epithelial ovarian cancer (OvCa) survival.

METHODS:

This is a single-institution retrospective cohort review of patients treated for OvCa between 1992 and 2013. Inclusion criteria were International Federation of Gynecology and Obstetrics (FIGO) stage I-IV OvCa. The primary exposures analyzed were hyperlipidemia and statin use. The primary outcomes were progression-free survival (PFS) and disease-specific survival (DSS).

RESULTS:

442 patients met inclusion criteria. The cohort was divided into three groups: patients with hyperlipidemia who used statins (n = 68), patients with hyperlipidemia who did not use statins (n = 28), and patients without hyperlipidemia (n = 346). OvCa outcomes were evaluated. When we analyzed the entire cohort, we found no significant differences in PFS or DSS among the groups. The median PFS for hyperlipidemics using statins, hyperlipidemics not using statins, and non-hyperlipidemics was 21.7, 13.6, and 14.7 months, respectively (p = 0.69). Median DSS for hyperlipidemics using statins, hyperlipidemics not using statins, and non-hyperlipidemics was 44.2, 75.7, and 41.5 months, respectively (p = 0.43). These findings did not change after controlling for confounders. However, a secondary analysis revealed that, among patients with non-serous-papillary subtypes of OvCa, statin use was associated with a decrease in hazards of both disease recurrence (adjusted HR = 0.23, p = 0.02) and disease-specific death (adjusted HR = 0.23, p = 0.04). To augment the findings in the retrospective cohort, the histology-specific effects of statins were also evaluated in vitro using proliferation assays. Here, statin treatment of cell lines resulted in a variable level of cytotoxicity.

CONCLUSION:

Statin use among patients with non-serous-papillary OvCa was associated with improvement in both PFS and DSS.

PMID:
25118694
PMCID:
PMC4131884
DOI:
10.1371/journal.pone.0104521
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Support Center