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Ann Clin Lab Sci. 2014 Summer;44(3):277-82.

Associations of single nucleotide polymorphisms related to insulin resistance with polycystic ovary syndrome.

Author information

1
Department of Laboratory Medicine.
2
Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea khmd.kim@samsung.com.
3
Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND:

We investigated and validated most of the hitherto-suggested polymorphisms for PCOS.

MATERIALS AND METHODS:

DNA samples from 359 pre-menopausal Korean women with PCOS (n=196) and without (n=166) were analyzed by primer extension and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry using iPLEX Gold technology from Sequenom (Sequenom Inc, San Diego, CA, USA) to determine the genotypic frequency of 80 single nucleotide polymorphisms (SNPs) from the 49 genes.

RESULTS:

Four SNPs (rs10060745, rs1719889, rs680, rs705379) showed moderate association with a risk of PCOS. Three (rs1719889, rs680, and rs705379) out of four SNPs were related to insulin resistance. The rs705379 showed significant association with increased fasting glucose (p=0.045) and serum 2-h C-peptide level (p=0.026). The rs1719889 showed significant association with fasting glucose level (p=0.03).

CONCLUSION:

Our results provide evidence for the relationship between high prevalence of insulin resistance and PCOS.

KEYWORDS:

Insulin resistance; Polycystic ovarian syndrome; Single nucleotide polymorphism

PMID:
25117097
[Indexed for MEDLINE]

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