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Case Rep Dent. 2014;2014:792615. doi: 10.1155/2014/792615. Epub 2014 Jul 10.

CTCFL (BORIS) mRNA Expression in a Peripheral Giant Cell Granuloma of the Oral Cavity.

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Laboratory of Molecular Stomatology, Faculty of Dentistry, Universidad Juárez de Estado de Durango, Predio Canoas Street, 34067 Durango, Mexico.
Department of Molecular Medicine, Faculty of Medicine and Nutrition, Universidad Juárez de Estado del Durango, Universidad Avenue, 34000 Durango, Mexico.
Laboratory of Pathology and Bucal Medicine, Faculty of Dentistry, Universidad Juárez del Estado de Durango, Predio Canoas Street, 34067 Durango, Mexico.
Faculty of Dentistry, Universidad Autónoma de Zacatecas, Begonias Street, Guadalupe, 98600 Zacatecas, Mexico.


Peripheral giant cell granuloma (PGCG) is a relatively common benign reactive lesion of the oral cavity which can occur at any age. CTCFL/BORIS (CTCF like/Brother of the Regulator of Imprinted Sites) and CTCF (CCCTC-binding factor) are paralogous genes with an important role in the regulation of gene expression, genomic imprinting, and nuclear chromatin insulators regulation. BORIS expression promotes cell immortalization and growth while CTCF has tumor suppressor activity; the expression pattern may reflect the reverse transcription silencing of BORIS. The aim of this work was to describe a histopathological and molecular approach of an 8-year-old pediatric male patient with PGCG diagnosis. It was observed that the PGCG under study expressed CTCF as well as BORIS mRNAs alongside with the housekeeping gene GAPDH, which may be related to possible genetic and epigenetic changes in normal cells of oral cavity.

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